2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-12219B
    MSI-1701 390808-64-7 98%
    MSI-1701 is an analogue of MSI-1436 which can control weight gain and blood glucose level extracted from patent US 7410959 B1.
    MSI-1701
  • HY-122307
    Sulisatin 54935-03-4 98%
    Sulisatin (DAN-603) is an anionic laxative that is hydrolyzed to diphenolic derivatives by bacterial aryl sulfate sulfohydrolases in the colon during oral administration.
    Sulisatin
  • HY-122338
    Fexarine 574013-67-5 98%
    Fexarine is a potent, non-steroidal and selective agonist of farnesoid X receptor (EC50: 38 nM). Fexarine can be used for the research of diseases linked to cholesterol, bile acids.
    Fexarine
  • HY-122416
    6,8-Diprenylnaringenin 68236-11-3 98%
    6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin.
    6,8-Diprenylnaringenin
  • HY-122455
    K-102 13835-19-3 98%
    K-102 is a small molecule agent that can be used for the study of nervous system diseases, endocrinology and metabolic disease.
    K-102
  • HY-122531
    Oleyl myristate 22393-93-7 98%
    Oleyl myristate is an ester product.
    Oleyl myristate
  • HY-122613
    YM543 free base 655237-16-4 98%
    YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes.
    YM543 free base
  • HY-122744
    CYP11B1-IN-1 2101952-78-5 98%
    CYP11B1-IN-1 is a selective, orally active hCYP11B1 inhibitor, with an IC50 of 2 nM against hCYP11B1 and an IC50 of 1.8 μM against rat CYP11B1. CYP11B1-IN-1 can be used for the research of Cushing's disease.
    CYP11B1-IN-1
  • HY-122782
    Lucidal 252351-96-5 98%
    Lucidal (Lucialdehyde C) is a natural lanostante-type triterpene aldehyde that shows inhibitory effects against α-glucosidase (Glucosidase) with an IC50 of 0.635 mM. Lucidal has anticancer and antidiabetic effects.
    Lucidal
  • HY-122916
    7-Acetyllycopsamine 73544-48-6 98%
    7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice.
    7-Acetyllycopsamine
  • HY-122959
    Kihadanin B 73793-68-7 98%
    Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
    Kihadanin B
  • HY-122963
    Danshenol B 189308-09-6 98%
    Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC50 value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy.
    Danshenol B
  • HY-122967
    Isosalvianolic acid C 142115-17-1 98%
    Isosalvianolic acid C is a phenolic compound that can be found in Lavandula angustifolia Mill.. Isosalvianolic acid C can be used as antioxidant.
    Isosalvianolic acid C
  • HY-123090
    11β-HSD1-IN-12 872506-67-7 98%
    11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome.
    11β-HSD1-IN-12
  • HY-12312A
    TCS 401 free base 243967-42-2 98%
    TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401 free base
  • HY-123165
    NU7200 842122-14-9 98%
    NU7200 is a metabolite of the DNA-PK inhibitor NU7026 (HY-15719).
    NU7200
  • HY-123171
    ASP8497 651055-26-4 98%
    ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research.
    ASP8497
  • HY-123181
    MK-0916 633317-53-0 98%
    MK-0916 is a HSD1 inhibitor. MK-0916 produces mechanism-based activation of the hypothalamic-pituitary-adrenal axis. MK-0916 can be used in the research of type 2 diabetes and metabolic syndromes.
    MK-0916
  • HY-123184
    S 1924 111371-30-3 98%
    S 1924 is a potent H+, K+-ATPase inhibitor, with IC50 values of 10.3 and 1.6 μM at pH 7.4 and pH 6.0, respectively.
    S 1924
  • HY-123207
    BP 554 82900-57-0 98%
    BP 554 is a selective 5-HT1A receptor agonist and Piperazine derivative. BP 554 leads to hypothermia.
    BP 554
Cat. No. Product Name / Synonyms Application Reactivity